Bitter hops extract (Humulus lupulus) can influence the vagus nerve through its impact on the gut-brain axis, particularly via the enteric nervous system (ENS). The bitter compounds in hops, including humulone and lupulone, interact with bitter taste receptors (TAS2Rs), which are present not only in the mouth but throughout the gut and even in the vagus nerve itself.
How Bitter Hops Extract Affects the Vagus Nerve
- Activates Bitter Taste Receptors in the Gut
The gut contains TAS2Rs, which respond to bitter compounds and can stimulate vagal afferents (sensory fibers of the vagus nerve).
Activation of these receptors influences digestion, gastric motility, and neurotransmitter release.
Influences the Parasympathetic Nervous System
The vagus nerve plays a major role in regulating the parasympathetic nervous system, which controls rest-and-digest functions.
Bitter stimulation from hops extract may enhance vagal tone, leading to improved digestion, reduced inflammation, and potential calming effects.
Modulates Neurotransmitters and Mood
Hops contain xanthohumol, a compound known to modulate GABA activity (gamma-aminobutyric acid), which is closely linked to vagus nerve function.
Since the vagus nerve connects to the brainstem and limbic system, bitter hops extract may have anxiolytic (anti-anxiety) and mild sedative effects.
Regulates Gut Motility and Appetite
The vagus nerve is responsible for regulating peristalsis (gut movement).
Bitter compounds in hops increase gastric secretions, improve bile flow, and may help with bloating or slow digestion by modulating vagal feedback loops.
Anti-Inflammatory Effects via the Cholinergic Pathway
The vagus nerve helps regulate systemic inflammation through the cholinergic anti-inflammatory pathway.
Hops extract has been studied for its anti-inflammatory and gut-soothing properties, which may further enhance vagal activity and reduce gut-brain inflammation.
Practical Effects of Bitter Hops on the Vagus Nerve
May Improve Digestion: Enhances gastric secretions and gut motility
Supports Relaxation & Sleep: Works on GABA pathways and vagus-related mood regulation.
May Help with IBS & Gut Disorders: Reduces inflammation via vagal pathways.
Could Enhance Vagal Tone: Supports parasympathetic dominance, reducing stress responses.
🚀 Curious about the product that’s been helping me reset my body?  Click Here To Learn More.
💬 Have you ever felt like your weight was more than just food? Email Me If You Want To Share Your Story.
💖 You Are Ready to Enjoy The Benefits of pHix 💖