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Feb 03 2025

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Jan 30 2025

The Science Of The Bitter Hops

💧THE SCIENCE OF THE BITTER HOPS 💧
THE POSITIVE EFFECTS ON COGNITION USING BITTER HOP EXTRACT

The Science of Bitter Hops Matured Hop-Derived Bitter Components in Beer Improve Hippocampus-Dependent Memory Through Activation of the Vagus Nerve

https://www.nature.com/articles/s41598-018-33866-1.pdf

Together, our results suggest that MHBA improves memory function via stimulation of the vagus nerve and enhancement of NE release in the hippocampus. Vagus nerve activation by the intake of food materials including MHBA may be a safe and effective approach for improving cognitive function.

2015

Matured Hop Bittering Components Induce Thermogenesis in Brown Adipose Tissue via Sympathetic Nerve Activity

Article on Brown Adipose Fat

Taken together, these findings indicate that MHB ameliorates diet-induced body fat accumulation, at least partly, by enhancing thermogenesis in BAT via BAT-SNA activation. Our data suggests that MHB is a useful tool for developing functional foods or beverages to counteract the accumulation of body fat.

2016

Matured hop extract reduces body fat in healthy overweight humans: a randomized, double-blind, placebo-controlled parallel group study

Study Group Report

Compared to the placebo group, a significant reduction was observed in the visceral fat area after 8 and 12 w, and in the total fat area after 12 w in the active group. The present study suggests that continual ingestion of MHE safely reduces body fat, particularly the abdominal visceral fat of healthy overweight subjects.

2018

The relationship between the effect of matured hop extract and physical activity on reducing body fat: re-analysis of data from a randomized, double-blind, placebo-controlled parallel group study

Relationship between Hops Extract & Exercise

The results suggested that MHE ingestion combined with light intensity exercise [walking] would induce a greater reduction in VFA which would be beneficial for obese or overweight individuals in reducing obesity and obesity-related diseases.

2018

Matured Hop-Derived Bitter Components in Beer Improve Hippocampus-Dependent Memory Through Activation of the Vagus Nerve

https://www.nature.com/articles/s41598-018-33866-1.pdf

2019

Effects of Hop Bitter Acids, Bitter Components in Beer, on Cognition in Healthy Adults: A Randomized Controlled Trial

https://pubs.acs.org/doi/10.1021/acs.jafc.9b06660

This is the first study to evaluate the effects of bitter ingredients in beer on cognition, subjective mood, and mental fatigue in a clinical trial. Our findings suggest that hop-derived bitter acids might be beneficial for cognition and mood state.

2020

Hop bitter acids containing a β‑carbonyl moiety prevent inflammation‑induced cognitive decline via the vagus nerve and noradrenergic system

https://www.nature.com/articles/s41598-020-77034-w.pdf

Bitter acids with a β‑tricarbonyl moiety suppress microglial activation and improve memory impairment induced by inflammation or AD pathology via the activation of the gut‑brain axis and noradrenergic system. Supplements with hop bitter acids, including MHBAs, might be a novel approach for the prevention of cognitive decline and dementia.

2020

Supplementation with Matured Hop Bitter Acids Improves Cognitive Performance and Mood State in Healthy Older Adults with Subjective Cognitive Decline

Bitter Hops Improves Cognition

This study suggested that MHBA intake improves cognitive function, attention, and mood state in older adults.

2022

An extract of hops (Humulus lupulus L.) modulates gut peptide hormone secretion and reduces energy intake in healthy-weight men: a randomized, crossover clinical trial

Peptide Hormone and Bitter Hops Extract

Both gastric and duodenal delivery of a hop extract modulates the release of hormones involved in appetite and glycemic regulation, providing a potential “bitter brake” on EI in healthy-weight men.

2023

Matured hop extract reduces body fat in healthy overweight humans: a randomized, double-blind, placebo-controlled parallel group study

Cognitive Functioning

Participants who consumed mature hop bitter acids showed significant improvements in cognitive performance, particularly in areas related to attention and memory.

Cognitive benefits are believed to be linked to the activation of dopamine neurotransmission in the brain, which enhances hippocampus-dependent memory and prefrontal cortex-associated cognitive functions.

Effects of Hop Bitter Acids, Bitter Components, on Cognition in Healthy Adults: A Randomized Controlled Trial | Journal of Agricultural and Food Chemistry

acs.org

Studies have shown that these MHBa increase dopaminergic activity in the hippocampus, a region of the brain associated with memory and emotional responses. This increase in activity is linked to improved mood, stress resilience and cognitive functions. Vagus nerve also stimulate the VTA a key region in the brain’s reward system.

The VTA contains dopamine-producing neurons which then act on the medial prefrontal cortex which is responsible for cognitive control, emotional regulation, motivation and reward processing, and attention allocation.

https://www.mdpi.com/1422-0067/21/24/9612?

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Jan 30 2025

How Bitter Hops Extract Affects the Vagus Nerve

Bitter hops extract (Humulus lupulus) can influence the vagus nerve through its impact on the gut-brain axis, particularly via the enteric nervous system (ENS). The bitter compounds in hops, including humulone and lupulone, interact with bitter taste receptors (TAS2Rs), which are present not only in the mouth but throughout the gut and even in the vagus nerve itself.

How Bitter Hops Extract Affects the Vagus Nerve

Activates Bitter Taste Receptors in the Gut

The gut contains TAS2Rs, which respond to bitter compounds and can stimulate vagal afferents (sensory fibers of the vagus nerve).

Activation of these receptors influences digestion, gastric motility, and neurotransmitter release.

Influences the Parasympathetic Nervous System

The vagus nerve plays a major role in regulating the parasympathetic nervous system, which controls rest-and-digest functions.

Bitter stimulation from hops extract may enhance vagal tone, leading to improved digestion, reduced inflammation, and potential calming effects.

Modulates Neurotransmitters and Mood

Hops contain xanthohumol, a compound known to modulate GABA activity (gamma-aminobutyric acid), which is closely linked to vagus nerve function.

Since the vagus nerve connects to the brainstem and limbic system, bitter hops extract may have anxiolytic (anti-anxiety) and mild sedative effects.

Regulates Gut Motility and Appetite

The vagus nerve is responsible for regulating peristalsis (gut movement).

Bitter compounds in hops increase gastric secretions, improve bile flow, and may help with bloating or slow digestion by modulating vagal feedback loops.

Anti-Inflammatory Effects via the Cholinergic Pathway

The vagus nerve helps regulate systemic inflammation through the cholinergic anti-inflammatory pathway.

Hops extract has been studied for its anti-inflammatory and gut-soothing properties, which may further enhance vagal activity and reduce gut-brain inflammation.

Practical Effects of Bitter Hops on the Vagus Nerve

May Improve Digestion: Enhances gastric secretions and gut motility

Supports Relaxation & Sleep: Works on GABA pathways and vagus-related mood regulation.

May Help with IBS & Gut Disorders: Reduces inflammation via vagal pathways.

Could Enhance Vagal Tone: Supports parasympathetic dominance, reducing stress responses.

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Jan 30 2025

What does the vagus nerve do with our body and what impact does it have on fat loss?

The vagus nerve is a crucial part of the autonomic nervous system, which controls involuntary bodily functions. It extends from the brainstem to various organs, including the heart, lungs, and digestive tract. Here are some of its primary functions and impacts, particularly related to fat loss:

1. **Regulation of Heart Rate**: The vagus nerve helps control heart rate and blood pressure, promoting relaxation and reducing stress, which can indirectly support fat loss by minimizing stress-related eating.

2. **Gastrointestinal Function**: It plays a significant role in digestion by stimulating the release of digestive enzymes and promoting gut motility. A well-functioning digestive system can help with nutrient absorption and may support metabolic health.

3. **Appetite Regulation**: The vagus nerve is involved in signaling fullness to the brain after eating. This can help regulate appetite and reduce overeating, which is important for weight management.

4. **Influence on Hormones**: The vagus nerve can affect the release of hormones involved in metabolism and fat storage, such as insulin and glucagon. This regulation can influence how the body stores and utilizes fat.

5. **Stress Response**: By modulating the body’s stress response, the vagus nerve can help reduce cortisol levels. Elevated cortisol can lead to increased fat storage, particularly in the abdominal area.

6. **Gut-Brain Axis**: The vagus nerve is a key component of the gut-brain axis, which links gut health to brain function. A healthy gut microbiome can influence weight management and metabolic health through this connection.

Overall, the vagus nerve’s functions can significantly impact metabolic processes and appetite regulation, thereby playing an essential role in fat loss and overall health.

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